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Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors in metastatic uveal melanoma

Uveal melanoma (UM) patients with metastatic disease usually die within one year, emphasizing an urgent need to develop new treatment strategies for this cancer. MEK inhibitors improve survival in cutaneous melanoma patients but show only modest efficacy in metastatic UM patients. In this study, we...

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Publicat a:Cancer Res
Autors principals: Cheng, Hanyin, Terai, Mizue, Kageyama, Ken, Ozaki, Shinji, McCue, Peter A., Sato, Takami, Aplin, Andrew E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490069/
https://ncbi.nlm.nih.gov/pubmed/25952648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0370
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