Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma

Frequent GNAQ and GNA11 mutations in uveal melanoma (UM) hyperactivate the MEK-ERK signaling pathway, leading to aberrant regulation of cyclin dependent kinases (CDK) and cell cycle progression. MEK inhibitors (MEKi) alone show poor efficacy in UM, raising the question of whether downstream targets...

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Publicado en:Mol Cancer Ther
Main Authors: Teh, Jessica L.F., Purwin, Timothy J., Han, Anna, Chua, Vivian, Patel, Prem, Baqai, Usman, Liao, Connie, Bechtel, Nelisa, Sato, Takami, Davies, Michael A., Aguirre-Ghiso, Julio, Aplin, Andrew E.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415561/
https://ncbi.nlm.nih.gov/pubmed/32430489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-1016
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