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CTLA4-Ig prolongs graft survival specifically in young but not old mice
Elderly organ transplant recipients have remained underrepresented in clinical trials, despite representing a rapidly growing population. Here, we assessed age-specific effects of CTLA4-Ig, a fusion protein blocking costimulatory signaling between APCs and T cells through CD28. Cardiac allografts in...
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| Publicado no: | Am J Transplant |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855762/ https://ncbi.nlm.nih.gov/pubmed/32717114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16218 |
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