Rapamycin prolongs graft survival and induces CD4(+)IFN-γ(+)IL-10(+) regulatory type 1 cells in old recipient mice

BACKGROUND: Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS: Here, we assessed the...

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Veröffentlicht in:Transplantation
Hauptverfasser: Quante, Markus, Heinbokel, Timm, Edtinger, Karoline, Minami, Koichiro, Uehara, Hirofumi, Nian, Yeqi, Azuma, Haruhito, Abdi, Reza, Elkhal, Abdallah, Tullius, Stefan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741485/
https://ncbi.nlm.nih.gov/pubmed/28777210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001902
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