Targeting age‐specific changes in CD4(+) T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to interfere with immunosuppressants have not been explored yet. Here, we dissected metabolic pathways of CD4(+) and CD8(+) T cells in aging and offer novel immunosuppressive targets. Upon activation, CD4(+) T cells fr...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Nian, Yeqi, Iske, Jasper, Maenosono, Ryoichi, Minami, Koichiro, Heinbokel, Timm, Quante, Markus, Liu, Yang, Azuma, Haruhito, Yang, Jinrui, Abdi, Reza, Zhou, Hao, Elkhal, Abdallah, Tullius, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884034/
https://ncbi.nlm.nih.gov/pubmed/33497523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13299
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