Targeting age‐specific changes in CD4(+) T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to interfere with immunosuppressants have not been explored yet. Here, we dissected metabolic pathways of CD4(+) and CD8(+) T cells in aging and offer novel immunosuppressive targets. Upon activation, CD4(+) T cells fr...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Nian, Yeqi, Iske, Jasper, Maenosono, Ryoichi, Minami, Koichiro, Heinbokel, Timm, Quante, Markus, Liu, Yang, Azuma, Haruhito, Yang, Jinrui, Abdi, Reza, Zhou, Hao, Elkhal, Abdallah, Tullius, Stefan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884034/
https://ncbi.nlm.nih.gov/pubmed/33497523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13299
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