Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Older organs represent an untapped potential to close the gap between demand and supply in organ transplantation but are associated with age-specific responses to injury and increased immunogenicity, thereby aggravating transplant outcomes. Here we show that cell-free mitochondrial DNA (cf-mt-DNA) r...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Iske, Jasper, Seyda, Midas, Heinbokel, Timm, Maenosono, Ryoichi, Minami, Koichiro, Nian, Yeqi, Quante, Markus, Falk, Christine S., Azuma, Haruhito, Martin, Friederike, Passos, João F., Niemann, Claus U., Tchkonia, Tamara, Kirkland, James L., Elkhal, Abdallah, Tullius, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453018/
https://ncbi.nlm.nih.gov/pubmed/32855397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18039-x
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