CTLA4-Ig prolongs graft survival specifically in young but not old mice

Elderly organ transplant recipients have remained underrepresented in clinical trials, despite representing a rapidly growing population. Here, we assessed age-specific effects of CTLA4-Ig, a fusion protein blocking costimulatory signaling between APCs and T cells through CD28. Cardiac allografts in...

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Publicado en:Am J Transplant
Autores principales: Heinbokel, Timm, Quante, Markus, Iske, Jasper, Nian, Yeqi, Maenosono, Ryoichi, Minami, Koichiro, Liu, Yang, Azuma, Haruhito, Elkhal, Abdallah, Tullius, Stefan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855762/
https://ncbi.nlm.nih.gov/pubmed/32717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16218
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