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Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking spiny projection neurons (SPNs) to cholinergic...

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Foilsithe in:Front Syst Neurosci
Main Authors: Lim, Sean Austin O., Surmeier, D. James
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854471/
https://ncbi.nlm.nih.gov/pubmed/33551760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsys.2020.626412
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