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Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice
The accumulation of abnormal prion protein (PrP(Sc)) produced by the structure conversion of PrP (PrP(C)) in the brain induces prion disease. Although the conversion process of the protein is still not fully elucidated, it has been known that the intramolecular chemical bridging in the most fragile...
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| Publicado no: | Neurotherapeutics |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7851219/ https://ncbi.nlm.nih.gov/pubmed/32767031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00903-9 |
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