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Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice

The accumulation of abnormal prion protein (PrP(Sc)) produced by the structure conversion of PrP (PrP(C)) in the brain induces prion disease. Although the conversion process of the protein is still not fully elucidated, it has been known that the intramolecular chemical bridging in the most fragile...

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Bibliografiske detaljer
Udgivet i:Neurotherapeutics
Main Authors: Ishibashi, Daisuke, Ishikawa, Takeshi, Mizuta, Satoshi, Tange, Hiroya, Nakagaki, Takehiro, Hamada, Tsuyoshi, Nishida, Noriyuki
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851219/
https://ncbi.nlm.nih.gov/pubmed/32767031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00903-9
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