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Novel Compounds Identified by Structure-Based Prion Disease Drug Discovery Using In Silico Screening Delay the Progression of an Illness in Prion-Infected Mice

The accumulation of abnormal prion protein (PrP(Sc)) produced by the structure conversion of PrP (PrP(C)) in the brain induces prion disease. Although the conversion process of the protein is still not fully elucidated, it has been known that the intramolecular chemical bridging in the most fragile...

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書誌詳細
出版年:Neurotherapeutics
主要な著者: Ishibashi, Daisuke, Ishikawa, Takeshi, Mizuta, Satoshi, Tange, Hiroya, Nakagaki, Takehiro, Hamada, Tsuyoshi, Nishida, Noriyuki
フォーマット: Artigo
言語:Inglês
出版事項: Springer International Publishing 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851219/
https://ncbi.nlm.nih.gov/pubmed/32767031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00903-9
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