Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Therapeutic strategies that target leukemic stem cells (LSC) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here we showed that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSC to tyrosine kinase inhibitor (TKI),...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Yahata, Takashi, Ibrahim, Abd Aziz, Hirano, Ken-ichi, Muguruma, Yukari, Naka, Kazuhito, Hozumi, Katsuto, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Fondazione Ferrata Storti 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849585/
https://ncbi.nlm.nih.gov/pubmed/32001531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.230227
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