Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Therapeutic strategies that target leukemic stem cells (LSC) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here we showed that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSC to tyrosine kinase inhibitor (TKI),...

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Bibliografski detalji
Izdano u:Haematologica
Glavni autori: Yahata, Takashi, Ibrahim, Abd Aziz, Hirano, Ken-ichi, Muguruma, Yukari, Naka, Kazuhito, Hozumi, Katsuto, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Format: Artigo
Jezik:Inglês
Izdano: Fondazione Ferrata Storti 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849585/
https://ncbi.nlm.nih.gov/pubmed/32001531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.230227
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