Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Therapeutic strategies that target leukemic stem cells (LSC) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here we showed that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSC to tyrosine kinase inhibitor (TKI),...

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Publicado en:Haematologica
Main Authors: Yahata, Takashi, Ibrahim, Abd Aziz, Hirano, Ken-ichi, Muguruma, Yukari, Naka, Kazuhito, Hozumi, Katsuto, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado: Fondazione Ferrata Storti 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849585/
https://ncbi.nlm.nih.gov/pubmed/32001531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.230227
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