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Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Presentation of peptides by class I MHC proteins underlies T cell immune responses to pathogens and cancer. The association between peptide binding affinity and immunogenicity has led to the engineering of modified peptides with improved MHC binding, with the hope that these peptides would be useful...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7848747/ https://ncbi.nlm.nih.gov/pubmed/33468649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018125118 |
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