Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner

Presentation of peptides by class I MHC proteins underlies T cell immune responses to pathogens and cancer. The association between peptide binding affinity and immunogenicity has led to the engineering of modified peptides with improved MHC binding, with the hope that these peptides would be useful...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Smith, Angela R., Alonso, Jesus A., Ayres, Cory M., Singh, Nishant K., Hellman, Lance M., Baker, Brian M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848747/
https://ncbi.nlm.nih.gov/pubmed/33468649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018125118
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk