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Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Presentation of peptides by class I MHC proteins underlies T cell immune responses to pathogens and cancer. The association between peptide binding affinity and immunogenicity has led to the engineering of modified peptides with improved MHC binding, with the hope that these peptides would be useful...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7848747/ https://ncbi.nlm.nih.gov/pubmed/33468649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018125118 |
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