γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

γ-Glutamyl carboxylase (GGCX) is an integral membrane protein that catalyzes posttranslational carboxylation of a number of vitamin K–dependent (VKD) proteins involved in a wide variety of physiologic processes, including blood coagulation, vascular calcification, and bone metabolism. Naturally occu...

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Bibliographic Details
Published in:Blood
Main Authors: Hao, Zhenyu, Jin, Da-Yun, Chen, Xuejie, Schurgers, Leon J., Stafford, Darrel W., Tie, Jian-Ke
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2021
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845004/
https://ncbi.nlm.nih.gov/pubmed/33507293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006329
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