A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Drug-induced bleeding disorders contribute to substantial morbidity and mortality. Antithrombotic agents that cause unintended bleeding of obvious cause are relatively easy to control. However, the mechanisms of most drug-induced bleeding disorders are poorly understood, which makes intervention mor...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Chen, Xuejie, Li, Caihong, Jin, Da-Yun, Ingram, Brian, Hao, Zhenyu, Bai, Xue, Stafford, Darrel W., Hu, Keping, Tie, Jian-Ke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426647/
https://ncbi.nlm.nih.gov/pubmed/32374827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004234
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