Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4(+) T cells in vivo

Clonal expansion of infected CD4(+) T cells is a major mechanism of HIV-1 persistence and a barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 integration, and interaction with antigens. Here, we show that it is possible to link antigen responsiveness, the...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Simonetti, Francesco R., Zhang, Hao, Soroosh, Garshasb P., Duan, Jiayi, Rhodehouse, Kyle, Hill, Alison L., Beg, Subul A., McCormick, Kevin, Raymond, Hayley E., Nobles, Christopher L., Everett, John K., Kwon, Kyungyoon J., White, Jennifer A., Lai, Jun, Margolick, Joseph B., Hoh, Rebecca, Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Siliciano, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843227/
https://ncbi.nlm.nih.gov/pubmed/33301425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI145254
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