Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease

Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. Therapeutics that lower HTT have shown preclinical promise and are being evaluated in clinical trials. However, clinical assessment of brain HTT lowering presents chall...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Neurosci
मुख्य लेखकों: Caron, Nicholas S., Banos, Raul, Yanick, Christopher, Aly, Amirah E., Byrne, Lauren M., Smith, Ethan D., Xie, Yuanyun, Smith, Stephen E.P., Potluri, Nalini, Findlay Black, Hailey, Casal, Lorenzo, Ko, Seunghyun, Cheung, Daphne, Kim, Hyeongju, Seong, Ihn Sik, Wild, Edward J., Song, Ji-Joon, Hayden, Michael R., Southwell, Amber L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Society for Neuroscience 2021
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842749/
https://ncbi.nlm.nih.gov/pubmed/33310753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1865-20.2020
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