Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease

Huntington disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. Therapeutics that lower HTT have shown preclinical promise and are being evaluated in clinical trials. However, clinical assessment of brain HTT lowering presents chall...

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Pubblicato in:J Neurosci
Autori principali: Caron, Nicholas S., Banos, Raul, Yanick, Christopher, Aly, Amirah E., Byrne, Lauren M., Smith, Ethan D., Xie, Yuanyun, Smith, Stephen E.P., Potluri, Nalini, Findlay Black, Hailey, Casal, Lorenzo, Ko, Seunghyun, Cheung, Daphne, Kim, Hyeongju, Seong, Ihn Sik, Wild, Edward J., Song, Ji-Joon, Hayden, Michael R., Southwell, Amber L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842749/
https://ncbi.nlm.nih.gov/pubmed/33310753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1865-20.2020
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