The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8(+) T cells to tumors

The Wnt/β-catenin pathway, which is associated with disease progression, is activated in many cancers. Tankyrase (TNKS) has received attention as a target molecule for Wnt/β-catenin pathway inhibition. We identified K-476, a novel TNKS inhibitor, a dual pocket binder that binds to both the nicotinam...

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Publicado en:Am J Cancer Res
Main Authors: Kinosada, Haruka, Okada-Iwasaki, Ryoko, Kunieda, Kana, Suzuki-Imaizumi, Minami, Takahashi, Yuichi, Miyagi, Hikaru, Suzuki, Michihiko, Motosawa, Keiichi, Watanabe, Miwa, Mie, Motoya, Ishii, Toshihiko, Ishida, Hiroshi, Saito, Jun-ichi, Nakai, Ryuichiro
Formato: Artigo
Idioma:Inglês
Publicado: e-Century Publishing Corporation 2021
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840722/
https://ncbi.nlm.nih.gov/pubmed/33520373
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