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Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors
[Image: see text] Tankyrases, an enzyme subfamily of human poly(ADP-ribosyl)polymerases, are potential drug targets especially against cancer. We have evaluated inhibition of tankyrases by known PARP inhibitors and report five cocrystal structures of the most potent compounds in complex with human t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2013
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027629/ https://ncbi.nlm.nih.gov/pubmed/24900770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400292s |
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