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Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors
[Image: see text] Tankyrases, an enzyme subfamily of human poly(ADP-ribosyl)polymerases, are potential drug targets especially against cancer. We have evaluated inhibition of tankyrases by known PARP inhibitors and report five cocrystal structures of the most potent compounds in complex with human t...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2013
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027629/ https://ncbi.nlm.nih.gov/pubmed/24900770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400292s |
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