2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors

Tankyrases (TNKSs) are enzymes specialized in catalyzing poly-ADP-ribosylation of target proteins. Several studies have validated TNKSs as anti-cancer drug targets due to their regulatory role in Wnt/β-catenin pathway. Recently a lot of effort has been put into developing more potent and selective T...

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Publicat a:Sci Rep
Autors principals: Nkizinkiko, Yves, Desantis, Jenny, Koivunen, Jarkko, Haikarainen, Teemu, Murthy, Sudarshan, Sancineto, Luca, Massari, Serena, Ianni, Federica, Obaji, Ezeogo, Loza, Maria I., Pihlajaniemi, Taina, Brea, Jose, Tabarrini, Oriana, Lehtiö, Lari
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785997/
https://ncbi.nlm.nih.gov/pubmed/29374194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19872-3
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