mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Activation of Wnt/β-catenin signaling is essential for colorectal carcinogenesis. Tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, is a positive regulator of the Wnt/β-catenin signaling. Accordingly, tankyrase inhibitors are under preclinical development for colorectal cancer (C...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mashima, Tetsuo, Taneda, Yoko, Jang, Myung-Kyu, Mizutani, Anna, Muramatsu, Yukiko, Yoshida, Haruka, Sato, Ayana, Tanaka, Noritaka, Sugimoto, Yoshikazu, Seimiya, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564614/
https://ncbi.nlm.nih.gov/pubmed/28615517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18146
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