RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model

Aberrant activation of Wnt/β‐catenin signaling causes tumorigenesis and promotes the proliferation of colorectal cancer cells. Porcupine inhibitors, which block secretion of Wnt ligands, may have only limited clinical impact for the treatment of colorectal cancer, because most colorectal cancer is c...

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發表在:Cancer Sci
Main Authors: Mizutani, Anna, Yashiroda, Yoko, Muramatsu, Yukiko, Yoshida, Haruka, Chikada, Tsubasa, Tsumura, Takeshi, Okue, Masayuki, Shirai, Fumiyuki, Fukami, Takehiro, Yoshida, Minoru, Seimiya, Hiroyuki
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272098/
https://ncbi.nlm.nih.gov/pubmed/30238564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13805
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