RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model

Aberrant activation of Wnt/β‐catenin signaling causes tumorigenesis and promotes the proliferation of colorectal cancer cells. Porcupine inhibitors, which block secretion of Wnt ligands, may have only limited clinical impact for the treatment of colorectal cancer, because most colorectal cancer is c...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Sci
Hlavní autoři: Mizutani, Anna, Yashiroda, Yoko, Muramatsu, Yukiko, Yoshida, Haruka, Chikada, Tsubasa, Tsumura, Takeshi, Okue, Masayuki, Shirai, Fumiyuki, Fukami, Takehiro, Yoshida, Minoru, Seimiya, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272098/
https://ncbi.nlm.nih.gov/pubmed/30238564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13805
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky