The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Liu, Yue, Tang, Wenqian, Ji, Chunhui, Gu, Jianghong, Chen, Yanmei, Huang, Jie, Zhao, Xinyi, Sun, Yingfang, Wang, Chengniu, Guan, Wei, Liu, Jianfeng, Jiang, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840484/
https://ncbi.nlm.nih.gov/pubmed/33519490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.624429
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