The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Liu, Yue, Tang, Wenqian, Ji, Chunhui, Gu, Jianghong, Chen, Yanmei, Huang, Jie, Zhao, Xinyi, Sun, Yingfang, Wang, Chengniu, Guan, Wei, Liu, Jianfeng, Jiang, Bo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840484/
https://ncbi.nlm.nih.gov/pubmed/33519490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.624429
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