In‐Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells

We report here the in‐cell NMR‐spectroscopic observation of the binding of the cognate ligand 2′‐deoxyguanosine to the aptamer domain of the bacterial 2′‐deoxyguanosine‐sensing riboswitch in eukaryotic cells, namely Xenopus laevis oocytes and in human HeLa cells. The riboswitch is sufficiently stabl...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Broft, P., Dzatko, S., Krafcikova, M., Wacker, A., Hänsel‐Hertsch, Robert, Dötsch, Volker, Trantirek, L., Schwalbe, Harald
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839747/
https://ncbi.nlm.nih.gov/pubmed/32975353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202007184
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