Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions

Methylation and demethylation of DNA, RNA and proteins has emerged as a major regulatory mechanism. Studying the function of these modifications would benefit from tools for their site‐specific inhibition and timed removal. S‐Adenosyl‐L‐methionine (AdoMet) analogs in combination with methyltransfera...

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Sparad:
Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Michailidou, Freideriki, Klöcker, Nils, Cornelissen, Nicolas V., Singh, Rohit K., Peters, Aileen, Ovcharenko, Anna, Kümmel, Daniel, Rentmeister, Andrea
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839696/
https://ncbi.nlm.nih.gov/pubmed/33017502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202012623
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