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Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

Cyclotides are macrocyclic peptides with exceptionally stable structures and have been reported to penetrate cells, making them promising scaffolds for the delivery of inhibitory peptides to target intracellular proteins. However, their cellular uptake and cytosolic localization have been poorly und...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Yin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J., Wang, Conan K.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7831380/
https://ncbi.nlm.nih.gov/pubmed/32315152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00297
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