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Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking

Cyclotides or cyclic cystine-knot peptides have emerged as a promising class of pharmacological ligands that modulate protein function. Interestingly, very few cyclotides have been shown to enter into cells. Yet, it remains unknown whether backbone cyclization is required for their cellular internal...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Gao, Xinxin, Stanger, Karen, Kaluarachchi, Harini, Maurer, Till, Ciepla, Paulina, Chalouni, Cecile, Franke, Yvonne, Hannoush, Rami N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062073/
https://ncbi.nlm.nih.gov/pubmed/27734922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35179
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