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Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

SIMPLE SUMMARY: Advanced breast cancer and prostate cancer metastasize to varying organs including the bone. We show here that mechanical loading to the knee suppresses tumor growth in the loaded bone and the non-loaded mammary pad. Although lipoprotein receptor-related protein 5 (Lrp5) in osteocyte...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Feng, Yan, Liu, Shengzhi, Zha, Rongrong, Sun, Xun, Li, Kexin, Robling, Alexander, Li, Baiyan, Yokota, Hiroki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828232/
https://ncbi.nlm.nih.gov/pubmed/33450808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13020267
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