Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

SIMPLE SUMMARY: Advanced breast cancer and prostate cancer metastasize to varying organs including the bone. We show here that mechanical loading to the knee suppresses tumor growth in the loaded bone and the non-loaded mammary pad. Although lipoprotein receptor-related protein 5 (Lrp5) in osteocyte...

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Bibliografiske detaljer
Udgivet i:	Cancers (Basel)
Main Authors:	Feng, Yan, Liu, Shengzhi, Zha, Rongrong, Sun, Xun, Li, Kexin, Robling, Alexander, Li, Baiyan, Yokota, Hiroki
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2021
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7828232/ https://ncbi.nlm.nih.gov/pubmed/33450808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13020267
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Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

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