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Inactivation of Lrp5 in Osteocytes Reduces Young’s Modulus and Responsiveness to the Mechanical Loading

Low-density-lipoprotein receptor-related protein 5 (Lrp5) is a co-receptor in Wnt signaling, which plays a critical role in development and maintenance of bone. Osteoporosis-pseudoglioma syndrome, for instance, arises from loss-of- function mutations in Lrp5, and global deletion of Lrp5 in mice resu...

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Autori principali: Zhao, Liming, Shim, Joon W., Dodge, Todd R., Robling, Alexander G., Yokota, Hiroki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602226/
https://ncbi.nlm.nih.gov/pubmed/23356985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.01.033
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