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Inactivation of Lrp5 in Osteocytes Reduces Young’s Modulus and Responsiveness to the Mechanical Loading
Low-density-lipoprotein receptor-related protein 5 (Lrp5) is a co-receptor in Wnt signaling, which plays a critical role in development and maintenance of bone. Osteoporosis-pseudoglioma syndrome, for instance, arises from loss-of- function mutations in Lrp5, and global deletion of Lrp5 in mice resu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602226/ https://ncbi.nlm.nih.gov/pubmed/23356985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.01.033 |
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