Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation

SIMPLE SUMMARY: Over the past two decades, there have been many published studies reporting high-copy SB transgenic lines in which the transposon allele includes both gene-trap and internal promoter elements to drive tumorigenesis in vivo. Cancer gene discovery from end-stage solid tumors in these s...

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Publicat a:Cancers (Basel)
Autors principals: Aiderus, Aziz, Contreras-Sandoval, Ana M., Meshey, Amanda L., Newberg, Justin Y., Ward, Jerrold M., Swing, Deborah A., Copeland, Neal G., Jenkins, Nancy A., Mann, Karen M., Mann, Michael B.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7827284/
https://ncbi.nlm.nih.gov/pubmed/33435458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13020225
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