Splicing factor SRSF1 controls T cell homeostasis and its decreased levels are linked to lymphopenia in systemic lupus erythematosus

OBJECTIVE: Lymphopenia is a frequent clinical manifestation and risk factor for infections in SLE, but the underlying mechanisms are not fully understood. We previously identified novel roles for the RNA-binding protein serine arginine-rich splicing factor 1 (SRSF1) in the control of genes involved...

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Bibliographische Detailangaben
Veröffentlicht in:Rheumatology (Oxford)
Hauptverfasser: Katsuyama, Takayuki, Martin-Delgado, Ignacio Juarez, Krishfield, Suzanne M, Kyttaris, Vasileios C, Moulton, Vaishali R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Basic and Translational Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825486/
https://ncbi.nlm.nih.gov/pubmed/32206811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa094
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