Ubiquitination Regulates Expression of the Serine/Arginine-rich Splicing Factor 1 (SRSF1) in Normal and Systemic Lupus Erythematosus (SLE) T Cells

T cells from patients with systemic lupus erythematosus (SLE) exhibit reduced expression of the critical T cell receptor (TCR)-associated CD3ζ signaling chain and are poor producers of the vital cytokine IL-2. By oligonucleotide pulldown and mass spectrometry discovery approaches, we identified the...

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Bibliographic Details
Main Authors: Moulton, Vaishali R., Gillooly, Andrew R., Tsokos, George C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924278/
https://ncbi.nlm.nih.gov/pubmed/24368769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518662
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