Aminoglycoside 6′-N-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions

Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram-negatives is the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib], which catalyzes acetylation using acetyl-CoA as...

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Bibliografiske detaljer
Udgivet i:Antibiotics (Basel)
Main Authors: Reeves, Craig M., Magallon, Jesus, Rocha, Kenneth, Tran, Tung, Phan, Kimberly, Vu, Peter, Yi, Yang, Oakley-Havens, Crista L., Cedano, José, Jimenez, Verónica, Ramirez, Maria S., Tolmasky, Marcelo E.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824292/
https://ncbi.nlm.nih.gov/pubmed/33396404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics10010029
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