Inhibitors of the Aminoglycoside 6′-N-Acetyltransferase type Ib [AAC(6′)-Ib] Identified by In-Silico Molecular Docking

AAC(6′)-Ib is an important aminoglycoside resistance enzyme to target with enzymatic inhibitors. An in-silico screening approach was used to identify potential inhibitors from the ChemBridge library. Several compounds were identified, of which two of them, 4-[(2-{[1-(3-methylphenyl)-4,6-dioxo-2-thio...

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Bibliografski detalji
Glavni autori: Lin, David L., Tran, Tung, Adams, Christina, Alam, Jamal Y., Herron, Steven, Tolmasky, Marcelo E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821527/
https://ncbi.nlm.nih.gov/pubmed/24011645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.016
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