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Inhibitors of the Aminoglycoside 6′-N-Acetyltransferase type Ib [AAC(6′)-Ib] Identified by In-Silico Molecular Docking
AAC(6′)-Ib is an important aminoglycoside resistance enzyme to target with enzymatic inhibitors. An in-silico screening approach was used to identify potential inhibitors from the ChemBridge library. Several compounds were identified, of which two of them, 4-[(2-{[1-(3-methylphenyl)-4,6-dioxo-2-thio...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821527/ https://ncbi.nlm.nih.gov/pubmed/24011645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.016 |
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