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Identification of an Inhibitor of the Aminoglycoside 6′-N-Acetyltransferase type Ib [AAC(6′)-Ib] by Glide Molecular Docking

The aminoglycoside 6’-N-acetyltransferase type Ib, AAC(6’)-Ib, confers resistance to clinically relevant aminoglycosides and is the most widely distributed enzyme among AAC(6’)-I-producing Gram-negative pathogens. An alternative to counter the action of this enzyme is the development of inhibitors....

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Chiem, Kevin, Jani, Saumya, Fuentes, Brooke, Lin, David L., Rasche, Madeline E., Tolmasky, Marcelo E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784703/
https://ncbi.nlm.nih.gov/pubmed/26973774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5MD00316D
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