Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant,

Enzymatic modification of aminoglycoside antibiotics mediated by regioselective aminoglycoside N-acetyltransferases is the predominant cause of bacterial resistance to aminoglycosides. A recently discovered bifunctional aminoglycoside acetyltransferase (AAC(6′)-Ib variant, AAC(6′)-Ib-cr) has been sh...

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Bibliographic Details
Main Authors: Vetting, Matthew W., Park, Chi Hye, Hegde, Subray S., Jacoby, George A., Hooper, David C., Blanchard, John S.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855648/
https://ncbi.nlm.nih.gov/pubmed/18710261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800664x
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