Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obscure. Using mouse models, we show that GTPases of...

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Udgivet i:eLife
Main Authors: Ghoroghi, Shima, Mary, Benjamin, Larnicol, Annabel, Asokan, Nandini, Klein, Annick, Osmani, Naël, Busnelli, Ignacio, Delalande, François, Paul, Nicodème, Halary, Sébastien, Gros, Frédéric, Fouillen, Laetitia, Haeberle, Anne-Marie, Royer, Cathy, Spiegelhalter, Coralie, André-Grégoire, Gwennan, Mittelheisser, Vincent, Detappe, Alexandre, Murphy, Kendelle, Timpson, Paul, Carapito, Raphaël, Blot-Chabaud, Marcel, Gavard, Julie, Carapito, Christine, Vitale, Nicolas, Lefebvre, Olivier, Goetz, Jacky G, Hyenne, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822591/
https://ncbi.nlm.nih.gov/pubmed/33404012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61539
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