Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes

The progressive neuropathological damage seen in Parkinson's disease (PD) is thought to be related to the spreading of aggregated forms of α‐synuclein. Clearance of extracellular α‐synuclein released by degenerating neurons may be therefore a key mechanism to control the concentration of α‐synu...

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Bibliografische gegevens
Gepubliceerd in:Glia
Hoofdauteurs: Filippini, Alice, Mutti, Veronica, Faustini, Gaia, Longhena, Francesca, Ramazzina, Ileana, Rizzi, Federica, Kaganovich, Alice, Roosen, Dorien A., Landeck, Natalie, Duffy, Megan, Tessari, Isabella, Bono, Federica, Fiorentini, Chiara, Greggio, Elisa, Bubacco, Luigi, Bellucci, Arianna, Missale, Mariacristina, Cookson, Mark R., Gennarelli, Massimo, Russo, Isabella
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
Onderwerpen:
Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821254/
https://ncbi.nlm.nih.gov/pubmed/33045109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23920
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