Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

Several previous studies have linked the Parkinson’s disease (PD) gene LRRK2 to the biology of microglia cells. However, the precise ways in which LRRK2 affects microglial function have not been fully resolved. Here, we used the RNA-Sequencing to obtain transcriptomic profiles of LRRK2 wild-type (WT...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Russo, Isabella, Kaganovich, Alice, Ding, Jinhui, Landeck, Natalie, Mamais, Adamantios, Varanita, Tatiana, Biosa, Alice, Tessari, Isabella, Bubacco, Luigi, Greggio, Elisa, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749993/
https://ncbi.nlm.nih.gov/pubmed/31102768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.05.012
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