Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the typical motor symptoms of Parkinson’s disease (PD). Lewy bodies (LB) and Lewy neurites (LN), proteinaceous inclusions mainly composed of insoluble α-synuclein (α-syn) fibrils are key neuropathological hallmarks o...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Bellucci, Arianna, Bubacco, Luigi, Longhena, Francesca, Parrella, Edoardo, Faustini, Gaia, Porrini, Vanessa, Bono, Federica, Missale, Cristina, Pizzi, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105602/
https://ncbi.nlm.nih.gov/pubmed/32265684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00068
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