NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

BACKGROUND: Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly composed of α-synuclein. We reported that mice deficient for NF-κB/c-Rel (c-rel(-/-))...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Parrella, Edoardo, Bellucci, Arianna, Porrini, Vanessa, Benarese, Marina, Lanzillotta, Annamaria, Faustini, Gaia, Longhena, Francesca, Abate, Giulia, Uberti, Daniela, Pizzi, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530198/
https://ncbi.nlm.nih.gov/pubmed/31139367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0154-z
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